Introduction: Human Papillomavirus (HPV) infection can also cause a number of anogenital malignancies, including head and neck cancers as well as cancers of the anus, vulva, vagina, and penis. Around 70% of all instances of cervical cancers are caused by HPV types 16 and 18. Nowadays, HPV vaccinations that offer defence against HPV 16 and 18 infections may lower the occurrence of cervical and other anogenital
malignancies. 
Objective: The study aimed to assess the awareness of female students regarding HPV and its vaccine, to assess the efficacy of a Structured Teaching Programme (STP) in increasing their awareness, and to analyse the
association of the awareness scores with selected demographic variables.
Method: The conceptual framework for the study was based on the CIPP model developed by Daniel Stufflebeam (1971). The study used a quantitative research strategy with a pre-experimental research design
with one group pretest post-test design. A standardised questionnaire was created to test female pupils’ awareness. The validity and reliability of the tool were established. Descriptive and inferential statistics were used to analyse data. Purposive sampling was used to get 130 samples.
Results: The study’s findings revealed that the majority of the subjects were in the age group of 12-14 years, with 78 (60%) followed by 52 (40%) in the age group of 15-17 years, and the data showed that there
was a gain in the post-test modified mean percentage in all content areas, indicating the effectiveness of structured teaching programmes. It was also shown that there is no significant relationship between pre-
test and post-test awareness scores and demographic characteristics.

Conclusion: The study’s findings demonstrated that structured teaching programmes were successful in improving awareness of the study subjects regarding HPV and its vaccine. Recommendations for future
research were proposed for the future based on the findings.

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